Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls. – PubMed – NCBI

Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls. – PubMed – NCBI:

Transgender persons experience incongruence between their gender identity and birth-assigned sex. The resulting gender dysphoria (GD), is frequently treated with cross-sex hormones. However, very little is known about how this treatment affects the brain of individuals with GD, nor do we know the neurobiology of GD. We recently suggested that disconnection of fronto-parietal networks involved in own-body self-referential processing could be a plausible mechanism, and that the anatomical correlate could be a thickening of the mesial prefrontal and precuneus cortex, which is unrelated to sex. Here, we investigate how cross-sex hormone treatment affects cerebral tissue in persons with GD, and how potential changes are related to self-body perception. Longitudinal MRI measurements of cortical thickness (Cth) were carried out in 40 transgender men (TrM), 24 transgender women (TrW) and 19 controls. Cth increased in the mesial temporal and insular cortices with testosterone treatment in TrM, whereas anti-androgen and oestrogen treatment in TrW caused widespread cortical thinning. However, after correction for treatment-related changes in total grey and white matter volumes (increase with testosterone; decrease with anti-androgen and oestrogen), significant Cth decreases were observed in the mesial prefrontal and parietal cortices, in both TrM and TrW (vs. controls) – regions showing greater pre-treatment Cth than in controls. The own body – self congruence ratings increased with treatment, and correlated with a left parietal cortical thinning. These data confirm our hypothesis that GD may be associated with specific anatomical features in own-body/self-processing circuits that reverse to the pattern of cisgender controls after cross-sex hormone treatment.

Structural Brain Differences for Transgender People

Structural Brain Differences for Transgender People:

A new study reveals that transgender people have variations in the size or volume of certain brain areas. Researchers at the University of São Paulo’s Medical School (FM-USP) in Brazil used magnetic resonance imaging (MRI) to assess the brain composition of transgender individuals.

The investigators performed a structural analysis in search of differences in gray and white matter volume based on MRI scans of the brains of 80 individuals between 18 and 49 years of age and found biological differences.

Brain Mapping Gender Identity: What Makes A Boy A Girl?

A recent brain mapping study investigates gender identity in a new, more scientific way.

An article written by Susan Scutti and posted at the Medical Daily reports on a study published last year which explores the extent to which brain anatomy is associated with gender identity.

About the study;

“Specifically, the UCLA researchers chose to investigate potential neuroanatomical variations associated with transsexualism; in particular, they applied a “whole-brain approach” in which they would compare the thickness of the cortex across the lateral and medial brain cortical surfaces at thousands of surface points.”

I’ve downloaded the PDF of the study.

From the Abstract;

“Background: The degree to which one identifies as male or female has a profound impact on one’s life. Yet, there is a limited understanding of what contributes to this important characteristic termed gender identity. In order to reveal factors influencing gender identity, studies have focused on people who report strong feelings of being the opposite sex, such as male-to-female (MTF) transsexuals. Method: To investigate potential neuroanatomical variations associated with transsexualism, we compared the regional thickness of the cerebral cortex between 24 MTF transsexuals who had not yet been treated with cross-sex hormones and 24 age-matched control males. Results: Results revealed thicker cortices in MTF transsexuals, both within regions of the left hemisphere (i.e., frontal and orbito-frontal cortex, central sulcus, perisylvian regions, paracentral gyrus) and right hemisphere (i.e., pre-/post-central gyrus, parietal cortex, temporal cortex, precuneus, fusiform, lingual, and orbito-frontal gyrus). Conclusion: These findings provide further evidence that brain anatomy is associated with gender identity, where measures in MTF transsexuals appear to be shifted away from gender-congruent men.”

Included is a list of references for further investigation.